Insulin resistance simply means that your cell membranes are not allowing insulin to transport glucose into your body cells to be burned as fuel. In fact, in many cases, the pancreas is already producing insulin at top capacity. But, many of these medications work by stimulating the pancreatic cells to produce even more insulin. Endeavoring to stimulate a drained pancreas results in loss of insulin-secreting cells. The drugs also increase fatty acid uptake in muscles and fat cells making you gain weight more easily. And with more weight you have increased insulin-resistance. Oral anti-diabetic agents are a "Catch 22". 2. Conventional Therapies Also Rely On Injecting Insulin Ten years of taking two to three shots of insulin a day left me in bad shape. I took insulin until I tipped the scales at almost 300 pounds. Insulin triggered my body to store excess carbohydrates as body fat. It slowed down my metabolism so I burned less ...